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ID 115679
Title Alternative
Clinical Guides for aHUS
Author
Kato, Hideki The University of Tokyo
Nangaku, Masaomi The University of Tokyo
Hataya, Hiroshi Tokyo Metropolitan Children’s Medical Center
Sawai, Toshihiro Shiga University of Medical Science
Ashida, Akira Osaka Medical College
Fujimaru, Rika Osaka City General Hospital
Hidaka, Yoshihiko Shinshu University
Kaname, Shinya Kyorin University
Maruyama, Shoichi Nagoya University
Yasuda, Takashi Kichijoji Asahi Hospital
Yoshida, Yoko The University of Tokyo
Ito, Shuichi Yokohama City University
Hattori, Motoshi Tokyo Women’s Medical University
Miyakawa, Yoshitaka Saitama Medical University
Fujimura, Yoshihiro Nara Medical University
Okada, Hirokazu Saitama Medical University
Keywords
alternative complement pathway
atypical hemolytic uremic syndrome
eculizumab
thrombotic microangiopathy
Content Type
Journal Article
Description
Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. In 2013, we developed diagnostic criteria to enable early diagnosis and timely initiation of appropriate treatment for aHUS. Recent clinical and molecular findings have resulted in several proposed classifications and definitions of thrombotic microangiopathy and aHUS. Based on recent advances in this field and the emerging international consensus to exclude secondary TMAs from the definition of aHUS, we have redefined aHUS and proposed diagnostic algorithms, differential diagnosis, and therapeutic strategies for aHUS.
Journal Title
Pediatrics International
ISSN
1442200X
Publisher
Japan Pediatric Society|Wiley
Volume
58
Issue
7
Start Page
549
End Page
555
Published Date
2016-07-26
Rights
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License(https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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language
eng
TextVersion
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departments
Medical Sciences