ID | 115725 |
Author |
Miyake, Yuka
Kyoto University
Ishikawa, Syungo
Kyoto University
Kimura, Yu
Kyoto University
Son, Aoi
Kyoto University
Imai, Hirohiko
Kyoto University
Matsuda, Tetsuya
Kyoto University
Yamada, Hisatsugu
Kyoto University|Tokushima University
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Toshimitsu, Akio
Kyoto University
Kondo, Teruyuki
Kyoto University
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Keywords | chiral dendrimer
gadolinium
contrast agent
magnetic resonance imaging (MRI)
quartz crystal microbalance (QCM)
association constant (Ka)
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Content Type |
Journal Article
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Description | Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r1) values about four times higher than that of clinically used Gd-DTPA (Magnevist®, Bayer). In our continuing study of pharmacokinetic differences derived from both the chirality and generation of Gd-MRI CAs, we found that the ability of chiral dendrimer Gd-MRI CAs to circulate within the body can be directly evaluated by in vitro MRI (7 T). In this study, the association constants (Ka) of chiral dendrimer Gd-MRI CAs to bovine serum albumin (BSA), measured and calculated with a quartz crystal microbalance (QCM) in vitro, were found to be an extremely easy means for evaluating the body-circulation ability of chiral dendrimer Gd-MRI CAs. The Ka values of S-isomeric dendrimer Gd-MRI CAs were generally greater than those of R-isomeric dendrimer Gd-MRI CAs, which is consistent with the results of our previous MRI study in vivo.
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Journal Title |
Sensors
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ISSN | 14248220
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Publisher | MDPI
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Volume | 15
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Issue | 12
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Start Page | 31973
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End Page | 31986
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Published Date | 2015-12-18
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Rights | This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
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language |
eng
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TextVersion |
Publisher
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departments |
Bioscience and Bioindustry
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