ID | 115725 |
著者 |
Miyake, Yuka
Kyoto University
Ishikawa, Syungo
Kyoto University
Kimura, Yu
Kyoto University
Son, Aoi
Kyoto University
Imai, Hirohiko
Kyoto University
Matsuda, Tetsuya
Kyoto University
Toshimitsu, Akio
Kyoto University
Kondo, Teruyuki
Kyoto University
|
キーワード | chiral dendrimer
gadolinium
contrast agent
magnetic resonance imaging (MRI)
quartz crystal microbalance (QCM)
association constant (Ka)
|
資料タイプ |
学術雑誌論文
|
抄録 | Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r1) values about four times higher than that of clinically used Gd-DTPA (Magnevist®, Bayer). In our continuing study of pharmacokinetic differences derived from both the chirality and generation of Gd-MRI CAs, we found that the ability of chiral dendrimer Gd-MRI CAs to circulate within the body can be directly evaluated by in vitro MRI (7 T). In this study, the association constants (Ka) of chiral dendrimer Gd-MRI CAs to bovine serum albumin (BSA), measured and calculated with a quartz crystal microbalance (QCM) in vitro, were found to be an extremely easy means for evaluating the body-circulation ability of chiral dendrimer Gd-MRI CAs. The Ka values of S-isomeric dendrimer Gd-MRI CAs were generally greater than those of R-isomeric dendrimer Gd-MRI CAs, which is consistent with the results of our previous MRI study in vivo.
|
掲載誌名 |
Sensors
|
ISSN | 14248220
|
出版者 | MDPI
|
巻 | 15
|
号 | 12
|
開始ページ | 31973
|
終了ページ | 31986
|
発行日 | 2015-12-18
|
権利情報 | This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
|
EDB ID | |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
|
著者版フラグ |
出版社版
|
部局 |
生物資源系
|