直近一年間の累計
アクセス数 : ?
ダウンロード数 : ?
ID 115725
著者
Miyake, Yuka Kyoto University
Ishikawa, Syungo Kyoto University
Kimura, Yu Kyoto University
Son, Aoi Kyoto University
Imai, Hirohiko Kyoto University
Matsuda, Tetsuya Kyoto University
Toshimitsu, Akio Kyoto University
Kondo, Teruyuki Kyoto University
キーワード
chiral dendrimer
gadolinium
contrast agent
magnetic resonance imaging (MRI)
quartz crystal microbalance (QCM)
association constant (Ka)
資料タイプ
学術雑誌論文
抄録
Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r1) values about four times higher than that of clinically used Gd-DTPA (Magnevist®, Bayer). In our continuing study of pharmacokinetic differences derived from both the chirality and generation of Gd-MRI CAs, we found that the ability of chiral dendrimer Gd-MRI CAs to circulate within the body can be directly evaluated by in vitro MRI (7 T). In this study, the association constants (Ka) of chiral dendrimer Gd-MRI CAs to bovine serum albumin (BSA), measured and calculated with a quartz crystal microbalance (QCM) in vitro, were found to be an extremely easy means for evaluating the body-circulation ability of chiral dendrimer Gd-MRI CAs. The Ka values of S-isomeric dendrimer Gd-MRI CAs were generally greater than those of R-isomeric dendrimer Gd-MRI CAs, which is consistent with the results of our previous MRI study in vivo.
掲載誌名
Sensors
ISSN
14248220
出版者
MDPI
15
12
開始ページ
31973
終了ページ
31986
発行日
2015-12-18
権利情報
This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
生物資源系