| ID | 117254 |
| Author |
Hiasa, Masahiro
Tokushima University
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Tanaka, Eiji
Tokushima University
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Abe, Masahiro
Tokushima University
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|
| Keywords | Multiple myeloma (Plasma cell myeloma)
Bone diseases
Osteoclasts
Osteoblasts
Osteocytes
|
| Content Type |
Journal Article
|
| Description | Multiple myeloma (Plasma cell myeloma), a malignancy of the plasma cells, exhibits tumor expansion preferentially in the bone marrow and the development of bone-destructive lesions. Multiple myeloma is still an incurable disease with changes in the bone marrow microenvironment in favor of the survival and proliferation of multiple myeloma cells and bone destruction. In this review, we described the recent findings on the regulators involved in the development of myeloma bone diseases, and succinctly summarize currently available therapeutic options and the development of novel bone modifying agents for myeloma treatment.
|
| Journal Title |
Japanese Dental Science Review
|
| ISSN | 18827616
|
| NCID | AA12334461
|
| Publisher | Japanese Association for Dental Science|Elsevier
|
| Volume | 57
|
| Start Page | 164
|
| End Page | 173
|
| Published Date | 2021-09-23
|
| Rights | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
| departments |
Oral Sciences
University Hospital
Medical Sciences
|
