Nakanishi, Nobuto Tokushima University
Tsutsumi, Rie Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hara, Kanako Tokushima University
Matsuo, Masafumi Kobe Gakuin University
Sakaue, Hiroshi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Oto, Jun Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
post-intensive care syndrome
Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. Titin breaks down to form urinary titin N-fragments, which are measurable in urine. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies have reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.
Journal of Clinical Medicine
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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