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ID 117763
Author
Ogura, Akihiro RIKEN
Nozaki, Satoshi RIKEN
Morimoto, Koji Osaka Women’s Junior College
Kizuka, Yasuhiko RIKEN
Kitazume, Shinobu RIKEN
Hara, Mitsuko RIKEN
Kojima, Soichi RIKEN
Onoe, Hirotaka RIKEN
Kurbangalieva, Almira Kazan Federal University
Taniguchi, Naoyuki RIKEN
Watanabe, Yasuyoshi RIKEN
Tanaka, Katsunori RIKEN|Kazan Federal University|Japan Science and Technology Agency
Content Type
Journal Article
Description
A series of N-glycans, each sequentially trimmed from biantennary sialoglycans, were homo- or heterogeneously clustered efficiently on fluorescent albumin using a method that combined strain-promoted alkyne-azide cyclization and 6π-azaelectrocyclization. Noninvasive in vivo kinetics and dissection analysis revealed, for the first time, a glycan-dependent shift from urinary to gall bladder excretion mediated by sequential trimming of non-reducing end sialic acids. N-glycoalbumins that were trimmed further, in particular, GlcNAc- and hybrid biantennary-terminated congeners, were selectively taken up by sinusoidal endothelial and stellate cells in the liver, which are critical for diagnosis and treatment of liver fibrillation. Our glycocluster strategy can not only reveal the previously unexplored extracellular functions of N-glycan trimming, but will be classified as the newly emerging glycoprobes for diagnostic and therapeutic applications.
Journal Title
Scientific Reports
ISSN
20452322
Publisher
Springer Nature
Volume
6
Start Page
21797
Published Date
2016-02-23
Rights
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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DOI (Published Version)
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language
eng
TextVersion
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departments
Advanced Research Promotion Center