ID | 119377 |
Title Alternative | 染色体パッセンジャー複合体構成因子であるBorealinの非古典的な機能は扁平上皮癌においてSurvivinの安定化を介して乳酸の産生を促進する
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Author |
Tawara, Hiroaki
Tokushima University
Tsunematsu, Takaaki
Tokushima University
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Kitajima, Shojiro
Keio University
Nagao, Ruka
Tokushima University
Matsuzawa, Shigefumi
Tokushima University
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Keywords | Chromosome passenger complex
Borealin
Survivin
glycolysis
squamous cell carcinoma
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Content Type |
Thesis or Dissertation
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Description | The chromosome passenger complex (CPC) is a kinase complex formed by Aurora B, borealin, survivin and inner centromere protein (INCENP). The CPC is active during mitosis and contributes to proper chromosome segregation via the phosphorylation of various substrates. Overexpression of each CPC component has been reported in most cancers. However, its significance remains unclear, as only survivin is known to confer chemoresistance. This study showed that the overexpression of borealin, a CPC component, stabilized survivin protein depending on its interaction with survivin. Unexpectedly, the accumulation of survivin by borealin overexpression did not affect the well-characterized functions of survivin, such as chemoresistance and cell proliferation. Interestingly, the overexpression of borealin promoted lactate production but not the overexpression of the deletion mutant that lacks the ability to bind to survivin. Consistent with these findings, the expression levels of glycolysis-related genes were enhanced in borealin-overexpressing cancer cells. Meanwhile, the overexpression of survivin alone did not promote lactate production. Overall, the accumulation of the borealin-survivin complex promoted glycolysis in squamous cell carcinoma cells. This mechanism may contribute to cancer progression via excessive lactate production.
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Journal Title |
Biochemical and Biophysical Research Communications
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ISSN | 0006291X
10902104
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NCID | AA00564395
AA11542044
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Publisher | Elsevier
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Volume | 706
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Start Page | 149741
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Published Date | 2024-03-06
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Hiroaki Tawaraの学位論文として提出され,学位審査・授与の対象となっている。 |
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DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3825号
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Diploma Number | 甲口第505号
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Granted Date | 2024-03-22
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Degree Name |
Doctor of Dental Science
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Grantor |
Tokushima University
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departments |
Medical Sciences
Institute of Post-LED Photonics
Oral Sciences
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