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ID 119377
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染色体パッセンジャー複合体構成因子であるBorealinの非古典的な機能は扁平上皮癌においてSurvivinの安定化を介して乳酸の産生を促進する
著者
俵, 宏彰 徳島大学大学院口腔科学研究科(口腔科学専攻)
Kitajima, Shojiro Keio University
Nagao, Ruka Tokushima University
Matsuzawa, Shigefumi Tokushima University
キーワード
Chromosome passenger complex
Borealin
Survivin
glycolysis
squamous cell carcinoma
資料タイプ
学位論文
抄録
The chromosome passenger complex (CPC) is a kinase complex formed by Aurora B, borealin, survivin and inner centromere protein (INCENP). The CPC is active during mitosis and contributes to proper chromosome segregation via the phosphorylation of various substrates. Overexpression of each CPC component has been reported in most cancers. However, its significance remains unclear, as only survivin is known to confer chemoresistance. This study showed that the overexpression of borealin, a CPC component, stabilized survivin protein depending on its interaction with survivin. Unexpectedly, the accumulation of survivin by borealin overexpression did not affect the well-characterized functions of survivin, such as chemoresistance and cell proliferation. Interestingly, the overexpression of borealin promoted lactate production but not the overexpression of the deletion mutant that lacks the ability to bind to survivin. Consistent with these findings, the expression levels of glycolysis-related genes were enhanced in borealin-overexpressing cancer cells. Meanwhile, the overexpression of survivin alone did not promote lactate production. Overall, the accumulation of the borealin-survivin complex promoted glycolysis in squamous cell carcinoma cells. This mechanism may contribute to cancer progression via excessive lactate production.
掲載誌名
Biochemical and Biophysical Research Communications
ISSN
0006291X
10902104
cat書誌ID
AA00564395
AA11542044
出版者
Elsevier
706
開始ページ
149741
発行日
2024-03-06
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Hiroaki Tawaraの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3825号
学位記番号
甲口第505号
学位授与年月日
2024-03-22
学位名
博士(歯学)
学位授与機関
徳島大学
部局
医学系
ポストLEDフォトニクス研究所
歯学系