ID | 119494 |
Author |
Thongkittidilok, Chommanart
Tokushima University
Lin, Qingyi
Tokushima University
Torigoe, Nanaka
Tokushima University
Liu, Bin
Tokushima University
Sato, Yoko
Tottori University
Nagahara, Megumi
Tokushima University
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Content Type |
Journal Article
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Description | Pigs rarely develop cancer; however, tumour protein p53 (TP53)-modified pigs may have an increased incidence of cancer. In this study, two pigs with mosaic mutations induced by gene editing were compared to determine the role of the wild-type TP53 sequence in tumorigenesis and to speculate how amino acid changes in TP53 sequences are related to tumorigenesis. The pig without tumours had a wild-type TP53 sequence and a 1-bp deletion in the TP53 sequence that resulted in a premature stop codon. In contrast, the pig with nephroblastoma had 6- and 7-bp deletions in the TP53 sequence, resulting in the absence of two amino acids and a premature stop codon, respectively. Our results indicated that TP53 mutations with truncated amino acids may be related to tumour formation.
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Journal Title |
Veterinary Medicine International
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ISSN | 20908113
20420048
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Publisher | Hindawi
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Volume | 2023
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Start Page | 7000858
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Published Date | 2023-08-14
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Rights | This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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DOI (Published Version) | |
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language |
eng
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Publisher
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departments |
Bioscience and Bioindustry
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