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ID 119494
著者
Lin, Qingyi Tokushima University
Torigoe, Nanaka Tokushima University
Liu, Bin Tokushima University
Sato, Yoko Tottori University
長原, 恵 Tokushima University
資料タイプ
学術雑誌論文
抄録
Pigs rarely develop cancer; however, tumour protein p53 (TP53)-modified pigs may have an increased incidence of cancer. In this study, two pigs with mosaic mutations induced by gene editing were compared to determine the role of the wild-type TP53 sequence in tumorigenesis and to speculate how amino acid changes in TP53 sequences are related to tumorigenesis. The pig without tumours had a wild-type TP53 sequence and a 1-bp deletion in the TP53 sequence that resulted in a premature stop codon. In contrast, the pig with nephroblastoma had 6- and 7-bp deletions in the TP53 sequence, resulting in the absence of two amino acids and a premature stop codon, respectively. Our results indicated that TP53 mutations with truncated amino acids may be related to tumour formation.
掲載誌名
Veterinary Medicine International
ISSN
20908113
20420048
出版者
Hindawi
2023
開始ページ
7000858
発行日
2023-08-14
権利情報
This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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出版社版DOI
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言語
eng
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出版社版
部局
生物資源系