ID 66339
Author
Sata, Masataka Department of Cardiovascular Medicine, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Fukuda, Daiju Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
atherosclerosis
renin-angiotensin system
reactive oxygen species
inflammation
Content Type
Journal Article
Description
The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the initiation and progression of atherosclerosis, thereby contributing to development of cardiovascular diseases. Angiotensin II (Ang II), a major substrate in RAS, stimulates atherosclerosis through various deleterious effects such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic actions of Ang II are mediated by reactive oxygen species (ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
1-2
Start Page
12
End Page
25
Sort Key
12
Published Date
2010-02
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
FullText File
language
eng
departments
Medical Sciences