ID 74427
Title Transcription
コウシ ヒカジュウ ニヨル キン イシュク カラ ノ カイフク カテイ ニ オヨボス DHEA トウヨ ノ コウカ
Title Alternative
Effects of DHEA Administration on Recovery from Rat Skeletal Muscle Atrophy Induced by Hind-limb Suspension
Author
Tanaka, Yoko Graduate School of Human and Natural Environment Sciences, The University of Tokushima
Matoba, Hideki Institute of Socio-Arts and Sciences, The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
DHEA
Muscle Atrophy
Oxidative stress
Content Type
Departmental Bulletin Paper
Description
The purpose of this study was to test the hypothesis that dehydroepiandrosterone (DHEA)
accelerate recovery from hind-limb suspension
-induced skeletal muscle atrophy in rats by relieving oxidative stress. Male
Wistar-strain rats aged 6 weeks were allocated either to the control group or
the hind-limb suspended group. Some rats of the suspended group were
sacrificed at the end of the suspension of 10 day long. Some other rats of the
suspended group were suspended and the allowed to recover for 5 days with
DHEA,25mg/kg/day or without DHEA. The rats of the control group were
sacrificed at either time points when the suspended rats were sacrificed. For
all rats, muscle mass, muscle protein concentration and content were
measured. Oxidative stress and anti-oxidative capacity of the serum and
skeletal muscles were also evaluated.
In the soleus muscle,DHEA did not accelerate the recovery of the muscle
mass from the suspension-induced atrophy, although it improved
anti-oxidative capacity. In the medial gastrocnemius muscle, DHEA
promoted the muscle mass recovery without altering a redox status of the
muscle. These results indicate that muscle mass recovery from
suspension-induced atrophy does not depend on redox status of the skeletal
muscle.
Journal Title
徳島大学総合科学部人間科学研究
ISSN
09199810
NCID
AN1043724X
Volume
17
Start Page
11
End Page
22
Sort Key
11
Published Date
2009
FullText File
language
jpn
departments
Integrated Arts and Sciences