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ID 74427
タイトルヨミ
コウシ ヒカジュウ ニヨル キン イシュク カラ ノ カイフク カテイ ニ オヨボス DHEA トウヨ ノ コウカ
タイトル別表記
Effects of DHEA Administration on Recovery from Rat Skeletal Muscle Atrophy Induced by Hind-limb Suspension
著者
田中, 陽子 徳島大学大学院人間・自然環境研究科
的場, 秀樹 徳島大学大学院ソシオ・アーツ・アンド・サイエンス研究部 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
DHEA
Muscle Atrophy
Oxidative stress
資料タイプ
紀要論文
抄録
The purpose of this study was to test the hypothesis that dehydroepiandrosterone (DHEA)
accelerate recovery from hind-limb suspension
-induced skeletal muscle atrophy in rats by relieving oxidative stress. Male
Wistar-strain rats aged 6 weeks were allocated either to the control group or
the hind-limb suspended group. Some rats of the suspended group were
sacrificed at the end of the suspension of 10 day long. Some other rats of the
suspended group were suspended and the allowed to recover for 5 days with
DHEA,25mg/kg/day or without DHEA. The rats of the control group were
sacrificed at either time points when the suspended rats were sacrificed. For
all rats, muscle mass, muscle protein concentration and content were
measured. Oxidative stress and anti-oxidative capacity of the serum and
skeletal muscles were also evaluated.
In the soleus muscle,DHEA did not accelerate the recovery of the muscle
mass from the suspension-induced atrophy, although it improved
anti-oxidative capacity. In the medial gastrocnemius muscle, DHEA
promoted the muscle mass recovery without altering a redox status of the
muscle. These results indicate that muscle mass recovery from
suspension-induced atrophy does not depend on redox status of the skeletal
muscle.
掲載誌名
徳島大学総合科学部人間科学研究
ISSN
09199810
cat書誌ID
AN1043724X
17
開始ページ
11
終了ページ
22
並び順
11
発行日
2009
フルテキストファイル
言語
jpn
部局
総合科学系