ID 77532
Author
Arai, Hidekazu Department of Laboratory of Clinical Nutrition Management, School of Food and Nutritional Sciences, the University of Shizuoka|Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Awane, Naomi Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Mizuno, Akira Department of Clinical Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
Fukaya, Makiko Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Sakuma, Masae Department of Laboratory of Clinical Nutrition Management, School of Food and Nutritional Sciences, the University of Shizuoka|Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Harada, Nagakatsu Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Kawaura, Akihiko Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Physical Therapy, School of Health Science, KIBI International University
Yamamoto, Hironori Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Okumura, Hisami Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Taketani, Yutaka Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Doi, Toshio Department of Clinical Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Takeda, Eiji Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
insulin-resistance
liver-cirrhosis
early-insulin-secretion
glucose-uptake
Content Type
Journal Article
Description
A number of recent publications have reported an increased frequency prevalence of glucose intolerance with hyperinsulinemia in liver cirrhosis. The aim of this work was to detect, in CCl4-induced liver cirrhosis rat, the presence and starting point of muscle and liver insulin resistance. Eighteen rats received intraperitoneal injection of 2 ml of soybean oil containing of CCl4 twice a week for 20 weeks. We executed standard oral glucose tolerance and clamp study to evaluate systemic insulin resistance. Hepatic glucose uptake was much lower in CCl4 group than that in control group, but peripheral glucose uptake was not decreased in this study. In contrast, early-phase insulin secretion was enhanced in CCl4 rat using oral glucose load during clamp methods. These data suggested that increased early insulin secretion compensate adequately for hepatic insulin resistance in rats. However there was a report that peripheral glucose uptake was decreased in the case of human liver cirrhosis, which was formed in the course of time. In a chronic condition, this may be associated with reduced insulin content and developed systemic insulin resistance in liver cirrhosis. Then a long term observation study will be required to examine the presence of muscle insulin resistance in liver cirrhosis.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
1-2
Start Page
54
End Page
61
Sort Key
54
Published Date
2010-02
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
departments
Medical Sciences