ID 77532
著者
新井, 英一 Department of Laboratory of Clinical Nutrition Management, School of Food and Nutritional Sciences, the University of Shizuoka|Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
アワネ, ナオミ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
水野, 昭 Department of Clinical Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
フカヤ, マキコ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
サクマ, マサエ Department of Laboratory of Clinical Nutrition Management, School of Food and Nutritional Sciences, the University of Shizuoka|Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
原田, 永勝 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
カワウラ, アキヒコ Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School|Department of Physical Therapy, School of Health Science, KIBI International University
山本, 浩範 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
奥村, 仙示 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
竹谷, 豊 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
土井, 俊夫 Department of Clinical Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
武田, 英二 Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
insulin-resistance
liver-cirrhosis
early-insulin-secretion
glucose-uptake
資料タイプ
学術雑誌論文
抄録
A number of recent publications have reported an increased frequency prevalence of glucose intolerance with hyperinsulinemia in liver cirrhosis. The aim of this work was to detect, in CCl4-induced liver cirrhosis rat, the presence and starting point of muscle and liver insulin resistance. Eighteen rats received intraperitoneal injection of 2 ml of soybean oil containing of CCl4 twice a week for 20 weeks. We executed standard oral glucose tolerance and clamp study to evaluate systemic insulin resistance. Hepatic glucose uptake was much lower in CCl4 group than that in control group, but peripheral glucose uptake was not decreased in this study. In contrast, early-phase insulin secretion was enhanced in CCl4 rat using oral glucose load during clamp methods. These data suggested that increased early insulin secretion compensate adequately for hepatic insulin resistance in rats. However there was a report that peripheral glucose uptake was decreased in the case of human liver cirrhosis, which was formed in the course of time. In a chronic condition, this may be associated with reduced insulin content and developed systemic insulin resistance in liver cirrhosis. Then a long term observation study will be required to examine the presence of muscle insulin resistance in liver cirrhosis.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
1-2
開始ページ
54
終了ページ
61
並び順
54
発行日
2010-02
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
233111
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
部局
医学系