ID 83263
Author
Yamamoto, Akihiro Department of Urology, Kochi Takasu Hospital
Sumiyoshi, Yoshiteru Department of Urology, National Shikoku Cancer Center Hospital
Miyake, Noriaki Department of Urology, Yashima General Hospital
Yokozeki, Hideaki Department of Urology, Tokushima Municipal Hospital
Kanayama, Hiro-omi Department of Urology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kagawa, Susumu Department of Urology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Prostate cancer
Luteinizing hormone-releasing hormone analogue
Disease flare
Chlormadinone acetate
Content Type
Journal Article
Description
We investigated the endocrinological effects of pretreatment with chlormadinone acetate (CMA) in preventing the initial testosterone surge induced by a luteinizing hormone-releasing hormone (LH-RH) analogue. A total of 25 patients with previously untreated prostate cancer were included in this study. The patients were randomly assigned to 2 treatment groups:Group1;CMA therapy was begun 4 weeks before the initial LH-RH analogue injection. Group 2;CMA therapy was begun 2 weeks before the initial LH-RH analogue injection. After the initial LH-RH analogue injection, CMA was administered during this study. After LH-RH analogue application, the mean values of serum luteinizing hormone (LH) and testosterone increased in both groups on day 3. However, LH and testosterone levels remained beneath pretreatment values in both groups. The mean relative PSA levels did not significantly increased on day 3 and day 7in both groups. Our results indicate that pretreatment with CMA for 2 weeks was sufficient to prevent the initial testosterone surge in the maximal androgen blockade which was associated with CMA.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
46
Issue
1-2
Start Page
55
End Page
58
Sort Key
55
Published Date
1999
Remark
FullText File
language
eng
departments
Medical Sciences