ID 83263
著者
ヤマモト, アキヒロ Department of Urology, Kochi Takasu Hospital
スミヨシ, ヨシテル Department of Urology, National Shikoku Cancer Center Hospital
ミヤケ, ノリアキ Department of Urology, Yashima General Hospital
横関, 秀明 Department of Urology, Tokushima Municipal Hospital
金山, 博臣 Department of Urology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
香川, 征 Department of Urology, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Prostate cancer
Luteinizing hormone-releasing hormone analogue
Disease flare
Chlormadinone acetate
資料タイプ
学術雑誌論文
抄録
We investigated the endocrinological effects of pretreatment with chlormadinone acetate (CMA) in preventing the initial testosterone surge induced by a luteinizing hormone-releasing hormone (LH-RH) analogue. A total of 25 patients with previously untreated prostate cancer were included in this study. The patients were randomly assigned to 2 treatment groups:Group1;CMA therapy was begun 4 weeks before the initial LH-RH analogue injection. Group 2;CMA therapy was begun 2 weeks before the initial LH-RH analogue injection. After the initial LH-RH analogue injection, CMA was administered during this study. After LH-RH analogue application, the mean values of serum luteinizing hormone (LH) and testosterone increased in both groups on day 3. However, LH and testosterone levels remained beneath pretreatment values in both groups. The mean relative PSA levels did not significantly increased on day 3 and day 7in both groups. Our results indicate that pretreatment with CMA for 2 weeks was sufficient to prevent the initial testosterone surge in the maximal androgen blockade which was associated with CMA.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
46
1-2
開始ページ
55
終了ページ
58
並び順
55
発行日
1999
備考
フルテキストファイル
言語
eng
部局
医学系