ID 83802
Author
Takahama, Yousuke Division of Experimental Immunology, Institute for Genome Research, University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
T lymphocyte
thymocyte
thymus
gene therapy
retrovirus
immune tolerance
Content Type
Journal Article
Description
T lymphocytes are the cells that play an essential role in regulating immune responses. The thymus is the organ in which T lymphocytes are generated. Our laboratory has investigated molecular signals that determine cell fate during T lymphocyte development in the thymus. To this goal, we have devised a technique in which one may efficiently introduce foreign genes into immature T lymphocytes. The somatic gene-transfer into developing T lymphocytes are likely useful to restore various immunodeficiencies and to establish immune tolerance to any introduced genes. The genetically engineered immune tolerance may be applied to reduce allergies and autoimmune diseases, as well as to sustain gene therapies by allowing prolonged survival of therapeutic vectors.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
48
Issue
1-2
Start Page
25
End Page
30
Sort Key
25
Published Date
2001
Remark
FullText File
language
eng
departments
Institute of Advanced Medical Sciences