ID 83838
Title Alternative
婦人科腹腔鏡下手術でニューロキニン1受容体拮抗薬アプレピタントは術後の嘔気・嘔吐を減少させる
NK-1 receptor antagonism decreases PONV
Author
Horikawa, Yousuke T. the University of Tokushima
Kawano, Hiroaki Tokushima University
Kinoshita, Michiko Tokushima University
Keywords
neurokinin-1 receptor
post-operative nausea and vomiting
aprepitant
laparoscopic gynecological surgery
Content Type
Thesis or Dissertation
Description
Purpose : Post-operative nausea and vomiting (PONV) remains the most frequently reported patient complaint after anesthesia. Aprepitant is the first neurokinin-1(NK1) receptor antagonism available for use as an antiemetic. We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery. Methods : Sixty four patients receiving general anesthesia for laparoscopic gynecological surgery were randomly assigned to either receive a preoperative dose of 80mg aprepitant or no drug. Efficacy was assessed in 2 and 24 hours after surgery. Primary and secondary endpoints were analyzed for the time intervals 0-2 hours (acute phase) and 2-24 hours (delayed phase). Vomiting, nausea, use of rescue anti-emetic, and visual analog scale (VAS) were assessed. Nausea was assessed on a 4-point scale, from 0 to 3. Results : Sixty patients participated in the study. At acute phase, PONV was present in both control and NK1 group and were 63% and 43% respectively. The severity of nausea was much less in the NK1 group. PONV prevalence at delayed phase was present in control but absent in NK1 group 27% vs. 0%, respectively. The amount of pain medication used by patients in the NK1 group was significantly less for diclofenac and pentazocine suggesting increase pain tolerance. Conclusions : Neurokinin-1 receptor antagonism effectively lowered PONV increased pain tolerance, and expedited recovery in patients undergoing laparoscopic gynecological surgery.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
58
Issue
3-4
Start Page
246
End Page
251
Sort Key
246
Published Date
2011-08
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201506051008.pdf
論文本文 : LID201506051009.pdf
本論文は,著者Nami Kakutaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2854号
Diploma Number
甲医第1250号
Granted Date
2015-04-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences