ID 83838
Author
Kakuta, Nami Department of Anesthesiology, Tokushima University Hospital, Institute of Health Bioscience, the University of Tokushima Graduate School|Department of Anesthesiology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tsutsumi, Yasuo M. Department of Anesthesiology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Horikawa, Yousuke T. Department of Anesthesiology, Institute of Health Bioscience, the University of Tokushima Graduate School
Kawano, Hiroaki Department of Anesthesiology, Tokushima University Hospital, Institute of Health Bioscience, the University of Tokushima Graduate School
Kinoshita, Michiko Department of Anesthesiology, Tokushima University Hospital, Institute of Health Bioscience, the University of Tokushima Graduate School
Tanaka, Katsuya Department of Anesthesiology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Oshita, Shuzo Department of Anesthesiology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
neurokinin-1 receptor
post-operative nausea and vomiting
aprepitant
laparoscopic gynecological surgery
Content Type
Journal Article
Description
Purpose : Post-operative nausea and vomiting (PONV) remains the most frequently
reported patient complaint after anesthesia. Aprepitant is the first neurokinin-
1(NK1) receptor antagonism available for use as an antiemetic. We investigated whether
aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological
surgery. Methods : Sixty four patients receiving general anesthesia for laparoscopic
gynecological surgery were randomly assigned to either receive a preoperative dose of 80
mg aprepitant or no drug. Efficacy was assessed in 2 and 24 hours after surgery. Primary
and secondary endpoints were analyzed for the time intervals 0-2 hours (acute phase)
and 2-24 hours (delayed phase). Vomiting, nausea, use of rescue anti-emetic, and visual
analog scale (VAS) were assessed. Nausea was assessed on a 4-point scale, from 0 to 3.
Results : Sixty patients participated in the study. At acute phase, PONV was present in
both control and NK1 group and were 63% and 43% respectively. The severity of nausea
was much less in the NK1 group. PONV prevalence at delayed phase was present in control
but absent in NK1 group 27% vs. 0%, respectively. The amount of pain medication used
by patients in the NK1 group was significantly less for diclofenac and pentazocine suggesting
increase pain tolerance. Conclusions : Neurokinin-1 receptor antagonism effectively
lowered PONV increased pain tolerance, and expedited recovery in patients undergoing
laparoscopic gynecological surgery.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
58
Issue
3-4
Start Page
246
End Page
251
Sort Key
246
Published Date
2011-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
FullText File
language
eng
departments
Medical Sciences