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ID 83838
タイトル別表記
婦人科腹腔鏡下手術でニューロキニン1受容体拮抗薬アプレピタントは術後の嘔気・嘔吐を減少させる
NK-1 receptor antagonism decreases PONV
著者
角田, 奈美 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧 KAKEN研究者をさがす
堤, 保夫 the University of Tokushima KAKEN研究者をさがす
ホリカワ, ヨウスケ the University of Tokushima
河野, 裕明 Tokushima University
キーワード
neurokinin-1 receptor
post-operative nausea and vomiting
aprepitant
laparoscopic gynecological surgery
資料タイプ
学位論文
抄録
Purpose : Post-operative nausea and vomiting (PONV) remains the most frequently reported patient complaint after anesthesia. Aprepitant is the first neurokinin-1(NK1) receptor antagonism available for use as an antiemetic. We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery. Methods : Sixty four patients receiving general anesthesia for laparoscopic gynecological surgery were randomly assigned to either receive a preoperative dose of 80mg aprepitant or no drug. Efficacy was assessed in 2 and 24 hours after surgery. Primary and secondary endpoints were analyzed for the time intervals 0-2 hours (acute phase) and 2-24 hours (delayed phase). Vomiting, nausea, use of rescue anti-emetic, and visual analog scale (VAS) were assessed. Nausea was assessed on a 4-point scale, from 0 to 3. Results : Sixty patients participated in the study. At acute phase, PONV was present in both control and NK1 group and were 63% and 43% respectively. The severity of nausea was much less in the NK1 group. PONV prevalence at delayed phase was present in control but absent in NK1 group 27% vs. 0%, respectively. The amount of pain medication used by patients in the NK1 group was significantly less for diclofenac and pentazocine suggesting increase pain tolerance. Conclusions : Neurokinin-1 receptor antagonism effectively lowered PONV increased pain tolerance, and expedited recovery in patients undergoing laparoscopic gynecological surgery.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
58
3-4
開始ページ
246
終了ページ
251
並び順
246
発行日
2011-08
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201506051008.pdf
論文本文 : LID201506051009.pdf
本論文は,著者Nami Kakutaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2854号
学位記番号
甲医第1250号
学位授与年月日
2015-04-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院