ID 83944
Author
Kuratate, Shinji Department of Surgery, Tokushima Prefectural Central Hospital
Inoue, Seiya Department of Surgery, Tokushima Prefectural Central Hospital Tokushima University Educator and Researcher Directory
Chikakiyo, Motoya Department of Surgery, Tokushima Prefectural Central Hospital
Kaneda, Yuji Department of Surgery, Tokushima Prefectural Central Hospital
Harino, Yukari Department of Surgery, Tokushima Prefectural Central Hospital
Hirose, Toshiyuki Department of Surgery, Tokushima Prefectural Central Hospital
Yagi, Toshiyuki Department of Surgery, Tokushima Prefectural Central Hospital
Saitoh, Seiya Department of Surgery, Tokushima Prefectural Central Hospital
Sumitomo, Masayuki Department of Surgery, Tokushima Prefectural Central Hospital
Fujino, Ryozo Department of Surgery, Tokushima Prefectural Central Hospital
Satake, Nobuo Department of Human Pathology, Tokushima Prefectural Central Hospital
Keywords
neuroendocrine cell carcinoma
rectum
adenoendocrine cell carcinoma
small cell carcinoma
Content Type
Journal Article
Description
A 74-years old man was referred to our hospital for treatment of a rectal mass.
Colonoscopy revealed villous tumor covering all the lower rectal lumen. Biopsy yielded
a diagnosis of adenoma. CT examination showed tumor shadows of the rectum and the
liver. Pelvic MRI examination showed a 10.5 8 7 cm tumor with high signal intensity on
the T2 weighted images in the rectum. Rectosigmoidectomy with lymph node dissection
was performed with the diagnosis of rectal cancer that metastasized to the liver. Histological
and immuno- histochemical features showed coexistent poorly-differentiated small
cell neuroendocrine cell (NEC) carcinoma and non-invasive well-differentiated adenocarcinoma
in tubulovillous adenoma. However the chemotherapy with FOLFOX and
Bevacizumab was performed postoperatively, the patient died in cancer 3 months after
surgery. Rectal poorly-differentiated NEC carcinomas are thought to be a tumor with a
high malignant potential. Recently, the UICC TNM classifications of malignant tumors,
7th edition and the Guidelines for colorectal NEC tumors of European Neuroendocrine
Tumor Society have been published. They would be evaluated, and effective multimodal
therapy for NEC carcinomas should be established.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
3-4
Start Page
338
End Page
344
Sort Key
338
Published Date
2010-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
FullText File
language
eng
departments
Medical Sciences