ID 97534
Title Transcription
サイキン カンセンショウ カンジャ ニオケル スタチン ノ タメンテキ コウカ
Title Alternative
Multiple effects of statins in patients with bacterial infectious diseases
Author
Nishitani, Noriko Graduate School of Pharmaceutical Sciences, the University of Tokushima|Faculty of Pharmaceutical Sciences, Hiroshima International University
Fushitani, Syuji Division of Pharmacy, Tokushima University Hospital
Shibata, Hirofumi Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Takiguchi, Masufumi Faculty of Pharmaceutical Sciences, Hiroshima International University
Kawazoe, Kazuyoshi Division of Pharmacy, Tokushima University Hospital|Department of Clinical Pharmacy, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Yoshihara, Shin’ichi Faculty of Pharmaceutical Sciences, Hiroshima International University
Minakuchi, Kazuo Division of Pharmacy, Tokushima University Hospital|Department of Clinical Pharmacy, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
statin
multiple effect
bacterial infection
sepsis
Content Type
Journal Article
Description
Statins, treatments for dyslipidemia, have been reported to possess effects leading to the repair of the vascular endothelium, as well as anti-oxidative and anti-inflammatory effects, and their clinical usefulness has been focused on. It was also reported in previous clinical research that bacteremia patients on statins showed a lower mortality compared to those not receiving statins, and atherosclerosis patients on statins showed a significantly lower rate of severe or fatal sepsis compared to those not receiving them. We conducted a case-control study involving patients hospitalized in Tokushima University Hospital to evaluate the relationship between taking/not taking statins and bacterial infectious diseases. As a result, there was no relationship between taking/not taking statins and the overall patients with bacterial infectious diseases, but sepsis patients on statins showed a significantly lower mortality. The taking of statins was suggested to be useful for patients with bacterial infectious diseases, particularly males.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
68
Issue
1-2
Start Page
29
End Page
34
Sort Key
29
Published Date
2012-04-25
Remark
EDB ID
FullText File
language
jpn
departments
Pharmaceutical Sciences
Medical Sciences