細菌感染症患者におけるスタチンの多面的効果

Statins, treatments for dyslipidemia, have been reported to possess effects leading to the repair of the vascular endothelium, as well as anti-oxidative and anti-inflammatory effects, and their clinical usefulness has been focused on. It was also reported in previous clinical research that bacteremia patients on statins showed a lower mortality compared to those not receiving statins, and atherosclerosis patients on statins showed a significantly lower rate of severe or fatal sepsis compared to those not receiving them. We conducted a case-control study involving patients hospitalized in Tokushima University Hospital to evaluate the relationship between taking／not taking statins and bacterial infectious diseases. As a result, there was no relationship between taking／not taking statins and the overall patients with bacterial infectious diseases, but sepsis patients on statins showed a significantly lower mortality. The taking of statins was suggested to be useful for patients with bacterial infectious diseases, particularly males.

四国医学雑誌 : http://www.tokushima-u.ac.jp/med/research/shikoku_acta_medica.html