ID | 74523 |
Title Alternative | ジェネティック制御下にある発育鶏卵を用いた工学的in vivo 薬剤評価系の開発
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Author |
Abe, Chiaki
Graduate School of Advanced Technology and Science, The University of Tokushima
Uto, Yoshihiro
Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima
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Nakata, Eiji
Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima
Hori, Hitoshi
Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima
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Keywords | Antioxidant
Artepillin C
Chick embryo chorioallantoic membrane
vascular injury
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Content Type |
Departmental Bulletin Paper
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Description | The drug discovery research of clinical-use antioxidants, which may control various vascular
disorders caused by the oxidative stress, is extremely important. We present the development of an in vivo evaluation system of antioxidants for their vascular protective activities using the chick embryonic chorioallantoic membrane (CAM). In the case of 12-days chick embryos, the topical administration of 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) induced their vascular injuries against the CAM veins and venous capillaries but without substantial fatal damage. Artepillin C, a potent natural antioxidant, did not show the chick embryo’s venous injury, and pre-treatment with artepillin C would tend to protect the CAM veins injuries induced by the post-administration of AAPH. These results suggest that artepillin C might be able to protect the AAPH-induced vascular injury in in vivo. In conclusion, we showed the possibility of in vivo evaluation system of antioxidants for their vascular protective activities using the chick embryo. |
Journal Title |
徳島大学大学院ソシオテクノサイエンス研究部研究報告
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ISSN | 21859094
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NCID | AA12214889
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Volume | 54
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Start Page | 70
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End Page | 74
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Sort Key | 70
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Published Date | 2009
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FullText File | |
language |
eng
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departments |
Bioscience and Bioindustry
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