ID | 74523 |
タイトル別表記 | ジェネティック制御下にある発育鶏卵を用いた工学的in vivo 薬剤評価系の開発
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著者 |
安部, 千秋
Graduate School of Advanced Technology and Science, The University of Tokushima
宇都, 義浩
Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima
徳島大学 教育研究者総覧
KAKEN研究者をさがす
中田, 栄司
Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima
堀, 均
Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima
徳島大学 教育研究者総覧
KAKEN研究者をさがす
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キーワード | Antioxidant
Artepillin C
Chick embryo chorioallantoic membrane
vascular injury
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資料タイプ |
紀要論文
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抄録 | The drug discovery research of clinical-use antioxidants, which may control various vascular
disorders caused by the oxidative stress, is extremely important. We present the development of an in vivo evaluation system of antioxidants for their vascular protective activities using the chick embryonic chorioallantoic membrane (CAM). In the case of 12-days chick embryos, the topical administration of 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) induced their vascular injuries against the CAM veins and venous capillaries but without substantial fatal damage. Artepillin C, a potent natural antioxidant, did not show the chick embryo’s venous injury, and pre-treatment with artepillin C would tend to protect the CAM veins injuries induced by the post-administration of AAPH. These results suggest that artepillin C might be able to protect the AAPH-induced vascular injury in in vivo. In conclusion, we showed the possibility of in vivo evaluation system of antioxidants for their vascular protective activities using the chick embryo. |
掲載誌名 |
徳島大学大学院ソシオテクノサイエンス研究部研究報告
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ISSN | 21859094
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cat書誌ID | AA12214889
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巻 | 54
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開始ページ | 70
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終了ページ | 74
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並び順 | 70
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発行日 | 2009
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フルテキストファイル | |
言語 |
eng
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部局 |
生物資源系
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