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ID 116231
Author
Lee, Sanghoon Tokushima University|Simon Fraser University
Takahashi, Sakura Tokushima University
Kim, Sang-Yong Health Sciences University of Hokkaido
Kojoma, Mareshige Health Sciences University of Hokkaido
Kobayashi, Jun’ichi Hokkaido University
Keywords
agesasines
bromopyrrole alkaloid
marine sponge
Agelas
Content Type
Journal Article
Description
Exploration for specialized metabolites of Okinawan marine sponges Agelas spp. resulted in the isolation of five new bromopyrrole alkaloids, agesasines A (1) and B (2), 9-hydroxydihydrodispacamide (3), 9-hydroxydihydrooroidin (4), and 9E-keramadine (5). Their structures were elucidated on the basis of spectroscopic analyses. Agesasines A (1) and B (2) were assigned as rare bromopyrrole alkaloids lacking an aminoimidazole moiety, while 3–5 were elucidated to be linear bromopyrrole alkaloids with either aminoimidazolone, aminoimidazole, or N-methylated aminoimidazole moieties.
Journal Title
Marine Drugs
ISSN
16603397
Publisher
MDPI
Volume
18
Issue
9
Start Page
455
Published Date
2020-08-30
Rights
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Bioscience and Bioindustry
Pharmaceutical Sciences