ID 111926
Author
Shimizu, Tatsuhiko Tokushima University
Miyajima, Rin Tokushima University
Naruse, Naoto Tokushima University
Yamaoka, Kosuke Tokushima University
Aihara, Keisuke Tokushima University
Keywords
C-terminal N-alkylamide
peptide thioacid
dethiocarboxylation
Content Type
Journal Article
Description
A new synthetic method has been developed to prepare peptides bearing a C-terminal N-alkylamide from peptide thioacids via a radical-initiated dethiocarboxylation process. This method enables the introduction of various alkyl groups to C-terminal amides simply by replacing the amino acid building block. Its application to the preparation of anti-cancer drug ABT-510 is also reported.
Journal Title
Chemical and Pharmaceutical Bulletin
ISSN
13475223
00092363
NCID
AA11695566
AA00602100
Publisher
The Pharmaceutical Society of Japan
Volume
64
Issue
4
Start Page
375
End Page
378
Published Date
2016-04-01
Rights
© 2016 The Pharmaceutical Society of Japan
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Pharmaceutical Sciences