| ID | 111926 |
| Author |
Shimizu, Tatsuhiko
Tokushima University
Miyajima, Rin
Tokushima University
Naruse, Naoto
Tokushima University
Yamaoka, Kosuke
Tokushima University
Aihara, Keisuke
Tokushima University
Otaka, Akira
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
|
| Keywords | C-terminal N-alkylamide
peptide thioacid
dethiocarboxylation
|
| Content Type |
Journal Article
|
| Description | A new synthetic method has been developed to prepare peptides bearing a C-terminal N-alkylamide from peptide thioacids via a radical-initiated dethiocarboxylation process. This method enables the introduction of various alkyl groups to C-terminal amides simply by replacing the amino acid building block. Its application to the preparation of anti-cancer drug ABT-510 is also reported.
|
| Journal Title |
Chemical and Pharmaceutical Bulletin
|
| ISSN | 13475223
00092363
|
| NCID | AA11695566
AA00602100
|
| Publisher | The Pharmaceutical Society of Japan
|
| Volume | 64
|
| Issue | 4
|
| Start Page | 375
|
| End Page | 378
|
| Published Date | 2016-04-01
|
| Rights | © 2016 The Pharmaceutical Society of Japan
|
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
| departments |
Pharmaceutical Sciences
|
