ID | 115048 |
Author |
Sato, Hiroyasu
The University of Tokyo|Tokyo Metropolitan Institute of Medical Science
Taketomi, Yoshitaka
The University of Tokyo|Tokyo Metropolitan Institute of Medical Science
Miki, Yoshimi
The University of Tokyo|Tokyo Metropolitan Institute of Medical Science
Murase, Remi
The University of Tokyo|Tokyo Metropolitan Institute of Medical Science
Yamamoto, Kei
Tokyo Metropolitan Institute of Medical Science|Tokushima University
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Murakami, Makoto
The University of Tokyo|Tokyo Metropolitan Institute of Medical Science|Japan Agency for Medical Research and Development
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Content Type |
Journal Article
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Description | Polyunsaturated fatty acids (PUFAs) confer health benefits by preventing inflammation and obesity and by increasing thermogenesis in brown and beige adipocytes. As well as being supplied exogenously as nutrients, PUFAs are largely stored in membrane glycerophospholipids and released by phospholipase A2s (PLA2s). However, the molecular identity of the PLA2 subtype(s) that supplies endogenous PUFAs for metabolic homeostasis remains unclear. Here we show that PLA2G2D, a secreted PLA2 isoform, is constitutively expressed in M2-type macrophages in white adipose tissue (WAT) and shows a reciprocal correlation with obesity. Studies using global and macrophage-specific Pla2g2d-deficient mice reveal that PLA2G2D increases energy expenditure and thermogenesis by facilitating adipocyte browning, thereby ameliorating diet-induced obesity, insulin resistance, and WAT inflammation. Mechanistically, PLA2G2D constitutively supplies a pool of PUFAs, ω3 in particular, in WAT. Thus, our present findings underscore the contribution of the macrophage-driven PLA2G2D-ω3 PUFA axis to metabolic health.
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Journal Title |
Cell Reports
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ISSN | 22111247
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Publisher | Elsevier
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Volume | 31
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Issue | 5
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Start Page | 107579
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Published Date | 2020-05-05
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Rights | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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DOI (Published Version) | |
URL ( Publisher's Version ) | |
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language |
eng
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TextVersion |
Publisher
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departments |
Bioscience and Bioindustry
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