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ID 115048
著者
Sato, Hiroyasu The University of Tokyo|Tokyo Metropolitan Institute of Medical Science
Taketomi, Yoshitaka The University of Tokyo|Tokyo Metropolitan Institute of Medical Science
Miki, Yoshimi The University of Tokyo|Tokyo Metropolitan Institute of Medical Science
Murase, Remi The University of Tokyo|Tokyo Metropolitan Institute of Medical Science
山本, 圭 Tokyo Metropolitan Institute of Medical Science|Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Murakami, Makoto The University of Tokyo|Tokyo Metropolitan Institute of Medical Science|Japan Agency for Medical Research and Development
資料タイプ
学術雑誌論文
抄録
Polyunsaturated fatty acids (PUFAs) confer health benefits by preventing inflammation and obesity and by increasing thermogenesis in brown and beige adipocytes. As well as being supplied exogenously as nutrients, PUFAs are largely stored in membrane glycerophospholipids and released by phospholipase A2s (PLA2s). However, the molecular identity of the PLA2 subtype(s) that supplies endogenous PUFAs for metabolic homeostasis remains unclear. Here we show that PLA2G2D, a secreted PLA2 isoform, is constitutively expressed in M2-type macrophages in white adipose tissue (WAT) and shows a reciprocal correlation with obesity. Studies using global and macrophage-specific Pla2g2d-deficient mice reveal that PLA2G2D increases energy expenditure and thermogenesis by facilitating adipocyte browning, thereby ameliorating diet-induced obesity, insulin resistance, and WAT inflammation. Mechanistically, PLA2G2D constitutively supplies a pool of PUFAs, ω3 in particular, in WAT. Thus, our present findings underscore the contribution of the macrophage-driven PLA2G2D-ω3 PUFA axis to metabolic health.
掲載誌名
Cell Reports
ISSN
22111247
出版者
Elsevier
31
5
開始ページ
107579
発行日
2020-05-05
権利情報
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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出版社版DOI
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フルテキストファイル
言語
eng
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出版社版
部局
生物資源系