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ID 115450
Title Alternative
Chemotherapy on QOL and night sleep of CC patients
Author
Okitsu, Hiroshi Tokushima Red Cross Hospital
Miyake, Hidenori Tokushima Municipal Hospital
Yagi, Toshiyuki Tokushima Prefectural Central Hospital
Miura, Murato Yoshinogawa Medical center
Bando, Yoshiaki Tokushima Prefectural Naruto Hospital
Ando, Tsutomu Tokushima Prefectural Miyoshi Hospital
Hotchi, Masanori Ehime Prefectural Central Hospital
Ishikawa, Masashi Shikoku Central Hospital
Fukuyama, Mitsutoshi Kochi National Hospital
Wada, Daisuke Takamatsu Municipal Hospital
Keywords
Chemotherapy
QOL
Sleep disturbance
Content Type
Journal Article
Description
Background : The aim of this study was to investigate quality of life (QOL) and night-time sleep disturbance in colon cancer patients with middle risk chemotherapy for proper antiemetic therapy. Methods : The study enrolled 139 patients with colorectal cancer. All patients received oxaliplatin or irinotecan-based chemotherapy. Patients completed a questionnaire about chemotherapy-induced nausea and vomiting and sleep disturbance. Sleep disturbance was checked, and the relationship between sleep disturbance and nausea was analyzed. Results : The prevalence of nausea was 48.9% (68 / 139). The degree of the nausea was slight / moderate / severe in 51 / 11 / 6 patients, and 12 patients had vomiting. Appetite showed no change / slightly decreased / half / one-fourth / none in 51 / 34 / 33 / 6 / 7 patients. There were significant differences in the mental component summary (MCS) score and the role-social component score (RCS). (MCS : nausea(+) vs nausea(-) 46.4 ± 1.1 vs 54.1 ± 1.1 p < 0.01 RCS : nausea(+) vs nausea(-) 33.1 ± 2.1 vs 41.6 ± 2.1 p < 0.01). Using the MCS with a cut-off score of 50, patients were divided into two groups, and nausea was significantly correlated with a low MCS score. Furthermore, patients were divided into two groups using a Pittsburgh Sleep Quality Index cut-off score of 6, and sleep disturbance was correlated with old age and second-line chemotherapy. Conclusions : Nausea affects QOL and night-time sleep of colon cancer patients with middle risk chemotherapy.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
67
Issue
3-4
Start Page
338
End Page
342
Sort Key
338
Published Date
2020-08
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences