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ID 114103
Author
Ogawa, Masatoshi Tokushima University
Zhou, Yu Tokushima University
Tsuji, Ryosuke Tokushima University
Keywords
6-OHDA
Mouse
Hind limb stepping
Hemi-parkinsonism
Content Type
Journal Article
Description
Unilateral injection of 6-hydroxydopamine (6-OHDA) is commonly used to generate a rodent model of Parkinson’s disease (PD). Although motor deficits of the lower extremities represent one of the major clinical symptoms in PD patients, validated tests for assessing motor impairments of the hind limb in 6-OHDA mice are currently unavailable. We here report the video-based assessments of the asymmetric use of hind limbs in 6-OHDA mice. A significantly decreased number of spontaneous hind limb stepping was observed in the contralateral-to-lesioned side, and was dose dependently reversed by levodopa, suggesting that it could be utilized for screening PD therapeutics.
Journal Title
Neuroscience Research
ISSN
01680102
NCID
AA10641652
AA11541052
Publisher
Elsevier
Volume
154
Start Page
56
End Page
59
Published Date
2019-05-16
Rights
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Medical Sciences
Pharmaceutical Sciences