| ID | 114103 |
| Author |
Ogawa, Masatoshi
Tokushima University
Zhou, Yu
Tokushima University
Tsuji, Ryosuke
Tokushima University
Kasahara, Jiro
Tokushima University
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|
| Keywords | 6-OHDA
Mouse
Hind limb stepping
Hemi-parkinsonism
|
| Content Type |
Journal Article
|
| Description | Unilateral injection of 6-hydroxydopamine (6-OHDA) is commonly used to generate a rodent model of Parkinson’s disease (PD). Although motor deficits of the lower extremities represent one of the major clinical symptoms in PD patients, validated tests for assessing motor impairments of the hind limb in 6-OHDA mice are currently unavailable. We here report the video-based assessments of the asymmetric use of hind limbs in 6-OHDA mice. A significantly decreased number of spontaneous hind limb stepping was observed in the contralateral-to-lesioned side, and was dose dependently reversed by levodopa, suggesting that it could be utilized for screening PD therapeutics.
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| Journal Title |
Neuroscience Research
|
| ISSN | 01680102
|
| NCID | AA10641652
AA11541052
|
| Publisher | Elsevier
|
| Volume | 154
|
| Start Page | 56
|
| End Page | 59
|
| Published Date | 2019-05-16
|
| Rights | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
|
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File |
neures_154_56_suppl_video1.mp4
5.16 MB
neures_154_56_suppl_video2.mp4
8.04 MB
neures_154_56_suppl_video3.mp4
9.31 MB
|
| language |
eng
|
| TextVersion |
Author
|
| departments |
Medical Sciences
Pharmaceutical Sciences
|
