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ID 114103
著者
Ogawa, Masatoshi Tokushima University
Zhou, Yu Tokushima University
Tsuji, Ryosuke Tokushima University
キーワード
6-OHDA
Mouse
Hind limb stepping
Hemi-parkinsonism
資料タイプ
学術雑誌論文
抄録
Unilateral injection of 6-hydroxydopamine (6-OHDA) is commonly used to generate a rodent model of Parkinson’s disease (PD). Although motor deficits of the lower extremities represent one of the major clinical symptoms in PD patients, validated tests for assessing motor impairments of the hind limb in 6-OHDA mice are currently unavailable. We here report the video-based assessments of the asymmetric use of hind limbs in 6-OHDA mice. A significantly decreased number of spontaneous hind limb stepping was observed in the contralateral-to-lesioned side, and was dose dependently reversed by levodopa, suggesting that it could be utilized for screening PD therapeutics.
掲載誌名
Neuroscience Research
ISSN
01680102
cat書誌ID
AA10641652
AA11541052
出版者
Elsevier
154
開始ページ
56
終了ページ
59
発行日
2019-05-16
権利情報
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
医学系
薬学系