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ID 106069
Title Alternative
肝細胞癌の肝内再発における非癌部でのCD44発現の役割
CD44 expression in HCC
Author
Tovuu, Lkhagva-Ochir The University of Tokushima
Utsunomiya, Tohru The University of Tokushima KAKEN Search Researchers
Hanaoka, Jun The University of Tokushima
Kanamoto, Mami The University of Tokushima KAKEN Search Researchers
Sugimoto, Koji The University of Tokushima
Asanoma, Michihito The University of Tokushima
Miyake, Hidenori The University of Tokushima
Keywords
hepatocellular carcinoma
CD44
prognostic factor
non tumor tissue
Content Type
Thesis or Dissertation
Description
Background: CD44 is well known to be one of the cancer stem cell markers and is a cell-surface glycoproteininvolved in cell-cell interactions, cell adhesion, and cell migration. We investigated the role of CD44 expression in both tumor and non-tumor tissues on recurrence of hepatocellular carcinoma (HCC).
Methods: Forty-eight patients with HCC who underwent hepatic resection at our institution were enrolled in this study. CD44 expressions in both tumor and non-tumor tissues were examined using real time reverse transcription-polymerase chain reaction. The patients were divided into two groups: high and low gene-expression group, based on the CD44 expression level. We compared the clinicopathological factors between the high expression and low expression groups in both tumor and non-tumor tissues.
Results: In the tumor tissues, the gene-expression levels of CD44 did not correlate with any clinicopathological parameters. The disease-free survival rate showed no significant difference between the two gourps. In non-tumor tissues, although there was no significant relationship between the CD44 expression levels and clinicopathological factors, disease-free survival rate in the CD44 low expression group was significantly better than that in the CD44 high expression group (p<0.05). In multivariate analysis, the risk factors in tumor recurrence were presence of microscopic portal invasion and high expression level of CD44.
Conclusion: The CD44 expressions in the non-tumor tissues may predict HCC recurrence.
Journal Title
International Journal of Clinical Oncology
ISSN
13419625
14377772
NCID
AA11086579
AA11625629
Publisher
Springer nature
Volume
18
Issue
4
Start Page
651
End Page
656
Published Date
2012-06-16
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201404221013.pdf
論文本文 : LID201410281001.pdf
本論文は, 著者Lkhagva-Ochir Tovuuの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2669号
Diploma Number
甲医第1189号
Granted Date
2014-03-24
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences