アクセス数 : ?
ダウンロード数 : ?
ID 106069
タイトル別表記
肝細胞癌の肝内再発における非癌部でのCD44発現の役割
CD44 expression in HCC
著者
トブゥ, ルハグワ オチル 徳島大学大学院医科学教育部(医学専攻)
宇都宮, 徹 The University of Tokushima KAKEN研究者をさがす
花岡, 潤 The University of Tokushima
金本, 真美 The University of Tokushima KAKEN研究者をさがす
Sugimoto, Koji The University of Tokushima
Asanoma, Michihito The University of Tokushima
三宅, 秀則 The University of Tokushima
キーワード
hepatocellular carcinoma
CD44
prognostic factor
non tumor tissue
資料タイプ
学位論文
抄録
Background: CD44 is well known to be one of the cancer stem cell markers and is a cell-surface glycoproteininvolved in cell-cell interactions, cell adhesion, and cell migration. We investigated the role of CD44 expression in both tumor and non-tumor tissues on recurrence of hepatocellular carcinoma (HCC).
Methods: Forty-eight patients with HCC who underwent hepatic resection at our institution were enrolled in this study. CD44 expressions in both tumor and non-tumor tissues were examined using real time reverse transcription-polymerase chain reaction. The patients were divided into two groups: high and low gene-expression group, based on the CD44 expression level. We compared the clinicopathological factors between the high expression and low expression groups in both tumor and non-tumor tissues.
Results: In the tumor tissues, the gene-expression levels of CD44 did not correlate with any clinicopathological parameters. The disease-free survival rate showed no significant difference between the two gourps. In non-tumor tissues, although there was no significant relationship between the CD44 expression levels and clinicopathological factors, disease-free survival rate in the CD44 low expression group was significantly better than that in the CD44 high expression group (p<0.05). In multivariate analysis, the risk factors in tumor recurrence were presence of microscopic portal invasion and high expression level of CD44.
Conclusion: The CD44 expressions in the non-tumor tissues may predict HCC recurrence.
掲載誌名
International Journal of Clinical Oncology
ISSN
13419625
14377772
cat書誌ID
AA11086579
AA11625629
出版者
Springer nature
18
4
開始ページ
651
終了ページ
656
発行日
2012-06-16
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201404221013.pdf
論文本文 : LID201410281001.pdf
本論文は, 著者Lkhagva-Ochir Tovuuの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2669号
学位記番号
甲医第1189号
学位授与年月日
2014-03-24
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系