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ID 115364
Title Alternative
Correlation between effects of checkpoint inhibitors and immune-related adverse events in patients with gastric cancer
胃癌における免疫チェックポイント阻害薬の副作用と効果の関連性
Author
Fujii, Shohei Tokushima University
Nakamura, Fumika Tokushima University
Kishi, Kazuhiro Tokushima municipal hospital
Keywords
Immune-checkpoint inhibitors
Gastric cancer
Immune-related adverse events
Nivolumab
Content Type
Journal Article
Description
Recently, immune checkpoint inhibitors(ICI)have been approved for use in advanced gastric cancer(AGC)based on the positive results of ATTRACTION‐2 trial in Japan. There has been accumulating evidence that the development of immune-related adverse events(irAE)may be associated with a response to ICI therapy, particularly in lung cancer, although little is known about these correlations in gastrointestinal cancer. To investigate the efficacy and irAE of ICI treatment and their correlation in AGC, we retrospectively examined 29 patients with AGC who received nivolumab therapy in our departments. Among them, 15 patients(52%)developed irAEs including 4 patients(14%)for grade 3 irAEs ; liver dysfunction(n=2), type 1 diabetes mellitus(n=2) and adrenal insufficiency(n=1). The median overall survival was12.0months in the irAE group and 3.25 months in the non-irAE group(p=0.164), which suggested the relationship between the effects and irAEs in ICI treatment of AGC. Further research is required to understand the implications of irAE characteristics on ICI response in GCA patients.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
76
Issue
3-4
Start Page
173
End Page
178
Sort Key
173
Published Date
2020-08-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital