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ID 115364
タイトル別表記
Correlation between effects of checkpoint inhibitors and immune-related adverse events in patients with gastric cancer
胃癌における免疫チェックポイント阻害薬の副作用と効果の関連性
著者
藤井, 祥平 徳島大学
中村, 文香 徳島大学
岸, 和弘 徳島市民病院
キーワード
Immune-checkpoint inhibitors
Gastric cancer
Immune-related adverse events
Nivolumab
資料タイプ
学術雑誌論文
抄録
Recently, immune checkpoint inhibitors(ICI)have been approved for use in advanced gastric cancer(AGC)based on the positive results of ATTRACTION‐2 trial in Japan. There has been accumulating evidence that the development of immune-related adverse events(irAE)may be associated with a response to ICI therapy, particularly in lung cancer, although little is known about these correlations in gastrointestinal cancer. To investigate the efficacy and irAE of ICI treatment and their correlation in AGC, we retrospectively examined 29 patients with AGC who received nivolumab therapy in our departments. Among them, 15 patients(52%)developed irAEs including 4 patients(14%)for grade 3 irAEs ; liver dysfunction(n=2), type 1 diabetes mellitus(n=2) and adrenal insufficiency(n=1). The median overall survival was12.0months in the irAE group and 3.25 months in the non-irAE group(p=0.164), which suggested the relationship between the effects and irAEs in ICI treatment of AGC. Further research is required to understand the implications of irAE characteristics on ICI response in GCA patients.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
76
3-4
開始ページ
173
終了ページ
178
並び順
173
発行日
2020-08-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系
病院