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ID 111438
Title Alternative
ゲラニルゲラニルアセトンはマウスにおいてストレスによるレプチン分泌の減少を防ぐ
GGA and leptin secretion
Author
Itai, Miki Tokushima University
Nishikawa, Tatsuya Tokushima University
Keywords
Geranylgeranylacetone
stress
food intake
leptin
ghrelin
Content Type
Thesis or Dissertation
Description
Geranylgeranylacetone (GGA) is a chaperon inducer that protects various types of cell and tissue against stress. We examined whether GGA modulated energy intake and expenditure under stressful conditions. After mice were untreated or treated orally with GGA (0.16 g per kg body weight per day) for 10 days, they were subjected to 2-h restraint stress once or once a day for 5 consecutive days. GGA administration did not affect corticosterone response to the stress. Restraint stress rapidly decreased plasma leptin levels in control mice. GGA significantly increased circulating leptin levels without changing food intake and prevented the stress-induced decline of circulating leptin. However GGA-treated mice significantly reduced food intake during the repeated stress, compared with control mice. GGA prevented the stress-induced decline of leptin mRNA and its protein levels in epidydimal adipose tissues. We also found that GGA decreased ghrelin mRNA expression in gastric mucosa before the stress, whereas GGA-treated mice recovered the ghrelin mRNA expression to the baseline level after the repeated stress. Leptin and ghrelin are now recognized as regulators of anxiety and depressive mood. Our results suggest that GGA may regulate food intake and relief stress-induced mood disturbance through regulating leptin and ghrelin secretions.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
65
Issue
1-2
Start Page
103
End Page
109
Sort Key
103
Published Date
2018-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Miki Itaiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3136号
Diploma Number
甲医第1370号
Granted Date
2018-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences