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ID 114219
Title Alternative
Analysis of Acid Dissociation Equilibrium of Bupropion by Capillary Zone Electrophoresis After Degradation Under Heat
Author
Itoh, Daichi Tokushima University
Keywords
Bupropion
Acid dissociation constant
Capillary zone electrophoresis
Heat degradation
Content Type
Journal Article
Description
An acid dissociation constant (pKa) of bupropion has been determined in an aqueous solution by capillary zone electrophoresis (CZE). Electrophoretic mobility of bupropion was measured by CZE over its acid-dissociating pH range, and a pKa value has been determined as 8.75±0.02 (mean ± standard error, ionic strength: 0.010 mol dm−3). Although bupropion degrades under heated and alkaline conditions and the degraded species from bupropion coexist in the aqueous solution, the pKa value of bupropion can also be determined by CZE with the residual bupropion without any interference from the degraded species. The pKa value determined after the heat-degradation was 8.74±0.02; the result agreed well with the one determined with the freshly prepared solution. Utilization of the separation characteristics of CZE has been demonstrated with bupropion for the analysis of the fast equilibrium of acid-base reaction under the coexistence of the degraded species.
Journal Title
Chromatography
ISSN
13483315
13428284
NCID
AA1137755X
Publisher
The Society for Chromatographic Sciences
Volume
37
Issue
3
Start Page
105
End Page
109
Published Date
2016-10-20
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Science and Technology