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ID 114219
タイトル別表記
Analysis of Acid Dissociation Equilibrium of Bupropion by Capillary Zone Electrophoresis After Degradation Under Heat
著者
Itoh, Daichi Tokushima University
キーワード
Bupropion
Acid dissociation constant
Capillary zone electrophoresis
Heat degradation
資料タイプ
学術雑誌論文
抄録
An acid dissociation constant (pKa) of bupropion has been determined in an aqueous solution by capillary zone electrophoresis (CZE). Electrophoretic mobility of bupropion was measured by CZE over its acid-dissociating pH range, and a pKa value has been determined as 8.75±0.02 (mean ± standard error, ionic strength: 0.010 mol dm−3). Although bupropion degrades under heated and alkaline conditions and the degraded species from bupropion coexist in the aqueous solution, the pKa value of bupropion can also be determined by CZE with the residual bupropion without any interference from the degraded species. The pKa value determined after the heat-degradation was 8.74±0.02; the result agreed well with the one determined with the freshly prepared solution. Utilization of the separation characteristics of CZE has been demonstrated with bupropion for the analysis of the fast equilibrium of acid-base reaction under the coexistence of the degraded species.
掲載誌名
Chromatography
ISSN
13483315
13428284
cat書誌ID
AA1137755X
出版者
The Society for Chromatographic Sciences
37
3
開始ページ
105
終了ページ
109
発行日
2016-10-20
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
理工学系