| ID | 113686 |
| Title Alternative | 神経障害性疼痛における三叉神経筋内のIL-10とCXCL2
|
| Author |
Iwasa, Takuma
Tokushima University
Afroz, Shaista
Tokushima University
Inoue, Miho
Tokushima University
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Oshima, Masamitsu
Tokushima University
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Raju, Resmi
Tokushima University
Waskitho, Arief
Tokushima University
Inoue, Masahisa
Tokushima Bunri University
Baba, Otto
Tokushima University
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|
| Keywords | Orofacial pain
Neuropathic pain
Sensory ganglia
Glial cell
Cytokine
Chemokine
|
| Content Type |
Thesis or Dissertation
|
| Description | Many trigeminal neuropathic pain patients suffer severe chronic pain. The neuropathic pain
might be related with cross-excitation of the neighboring neurons and satellite glial cell (SGCs) in the sensory ganglia and increasing the pain signals from the peripheral tissue to the central nervous system. We induced trigeminal neuropathic pain by infraorbital nerve constriction injury (IONC) in Sprague-Dawley rats. We tested cytokine (CXCL2 and IL-10) levels in trigeminal ganglia (TGs) after trigeminal neuropathic pain induction, and the effect of direct injection of the anti-CXCL2 and recombinant IL-10 into TG. We found that IONC induced pain behavior. Additionally, IONC induced satellite glial cell activation in TG and cytokine levels of TGs were changed after IONC. CXCL2 levels increased on day 1 of neuropathic pain induction and decreased gradually, with IL-10 levels showing the opposite trend. Recombinant IL-10 or anti-CXCL2 injection into TG decreased pain behavior. Our results show that IL-10 or anti-CXCL2 are therapy options for neuropathic pain. |
| Journal Title |
Neuroscience Letters
|
| ISSN | 03043940
|
| NCID | AA11540956
AA00754925
|
| Publisher | Elsevier
|
| Volume | 703
|
| Start Page | 132
|
| End Page | 138
|
| Published Date | 2019-03-20
|
| Remark | 内容要旨・審査要旨・論文本文の公開
本論文は，著者Takuma Iwasaの学位論文として提出され，学位審査・授与の対象となっている。 |
| Rights | © 2019 Elsevier B.V. All rights reserved.
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
ETD
|
| MEXT report number | 甲第3317号
|
| Diploma Number | 甲口第449号
|
| Granted Date | 2019-06-13
|
| Degree Name |
Doctor of Dental Science
|
| Grantor |
Tokushima University
|
| departments |
Oral Sciences
|
