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ID 113572
Author
Qi, Guangying Guilin Medical University
Liu, Jing Guilin Medical University
Mi, Sisi Guilin Medical University
Jin, Shengjian Guilin Medical University
Shao, Wenhua Guilin Medical University
Liu, Tian Guilin Medical University
Tang, Bo Guilin Medical University
Keywords
Aurora kinases
Mitosis
Head and neck cancer
Aurora kinase inhibitor
Content Type
Journal Article
Description
Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represents a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.
Journal Title
Current Topics in Medicinal Chemistry
ISSN
15680266
18734294
NCID
AA11692499
AA12814900
Publisher
Bentham Science
Volume
18
Issue
3
Start Page
199
End Page
213
Published Date
2018
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Medical Sciences
Oral Sciences