ID 113572
著者
Qi, Guangying Guilin Medical University
Liu, Jing Guilin Medical University
Mi, Sisi Guilin Medical University
Jin, Shengjian Guilin Medical University
Shao, Wenhua Guilin Medical University
Liu, Tian Guilin Medical University
Tang, Bo Guilin Medical University
キーワード
Aurora kinases
Mitosis
Head and neck cancer
Aurora kinase inhibitor
資料タイプ
学術雑誌論文
抄録
Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represents a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.
掲載誌名
Current Topics in Medicinal Chemistry
ISSN
15680266
18734294
cat書誌ID
AA11692499
AA12814900
出版者
Bentham Science
18
3
開始ページ
199
終了ページ
213
発行日
2018
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
医学系
歯学系