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ID 114712
Title Alternative
ヒト歯髄幹細胞由来培養上清による皮膚の放射線障害の抑制効果
Dental pulp stem cell factors for treating RISR
Author
Kawarabayashi, Keita Tokushima University
Hibi, Hideharu Nagoya University
Keywords
human dental pulp stem cells
conditioned media
mesenchymal stem cells
radiation-induced skin reaction
cutaneous radiation syndrome
radiation-induced skin reactions
Content Type
Thesis or Dissertation
Description
Radiation-induced skin ulceration is a frequent complication of radiotherapy for cancer treatment. Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues. In this study, we investigated the impact of SHED-conditioned media (SHED-CM) on radiation-induced ulceration. Mouse necks were locally irradiated with a single dose of 15 Gy of radiation. A week after the irradiation, most of the wild-type mice generated ulcer surrounded by severe erythema. Intra-venous administration of SHED-CM effectively inhibited the ulcer formation. Histological examination revealed that SHED-CM treatment inhibited radiation-induced dermal thickness and epithelial hyperplasia. SHED-CM could be a useful treatment option for radiation-induced skin ulceration.
Journal Title
Journal of Oral Health and Biosciences
ISSN
21896682
Publisher
Shikoku Society of Dental Research
Volume
33
Issue
1
Start Page
1
End Page
7
Sort Key
1
Published Date
2020-06-12
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Keita Kawarabayashiの学位論文として提出され,学位審査・授与の対象となっている。
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3382号
Diploma Number
甲口第461号
Granted Date
2020-03-23
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
Oral Sciences