| ID | 114712 |
| タイトル別表記 | ヒト歯髄幹細胞由来培養上清による皮膚の放射線障害の抑制効果
Dental pulp stem cell factors for treating RISR
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| 著者 |
Hibi, Hideharu
Nagoya University
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| キーワード | human dental pulp stem cells
conditioned media
mesenchymal stem cells
radiation-induced skin reaction
cutaneous radiation syndrome
radiation-induced skin reactions
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| 資料タイプ |
学位論文
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| 抄録 | Radiation-induced skin ulceration is a frequent complication of radiotherapy for cancer treatment. Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues. In this study, we investigated the impact of SHED-conditioned media (SHED-CM) on radiation-induced ulceration. Mouse necks were locally irradiated with a single dose of 15 Gy of radiation. A week after the irradiation, most of the wild-type mice generated ulcer surrounded by severe erythema. Intra-venous administration of SHED-CM effectively inhibited the ulcer formation. Histological examination revealed that SHED-CM treatment inhibited radiation-induced dermal thickness and epithelial hyperplasia. SHED-CM could be a useful treatment option for radiation-induced skin ulceration.
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| 掲載誌名 |
Journal of Oral Health and Biosciences
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| ISSN | 21896682
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| 出版者 | Shikoku Society of Dental Research
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| 巻 | 33
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| 号 | 1
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| 開始ページ | 1
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| 終了ページ | 7
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| 並び順 | 1
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| 発行日 | 2020-06-12
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| 備考 | 内容要旨・審査要旨・論文本文の公開
本論文は，著者Keita Kawarabayashiの学位論文として提出され，学位審査・授与の対象となっている。 |
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| 出版社版DOI | |
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| フルテキストファイル | |
| 言語 |
eng
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| 著者版フラグ |
博士論文全文を含む
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| 文科省報告番号 | 甲第3382号
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| 学位記番号 | 甲口第461号
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| 学位授与年月日 | 2020-03-23
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| 学位名 |
博士（歯学）
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| 学位授与機関 |
徳島大学
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| 部局 |
歯学系
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