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ID 115079
Title Alternative
Regeneration of complex oral organs
Cell differentiation and development
Author
Ogawa, Miho RIKEN Center for Developmental Biology|Organ Technologies
Tsuji, Takashi RIKEN Center for Developmental Biology|Organ Technologies
Content Type
Journal Article
Description
The development of organoid techniques for regenerative therapy has progressed remarkably with the use of tissue-derived stem cells and pluripotent stem cells based on stem cell biology and tissue engineering technology. To realize whole-organ replacement therapy as next-generation regenerative medicine, it is expected that fully functional bioengineered organs can be reconstructed using an in vitro three-dimensional (3D) bioengineered organ germ and organoids by stem cell manipulation and self-organization. In this mini-review, we focused on substantial advances of 3D bioengineering technologies for the regeneration of complex oral organs with the reconstruction of 3D bioengineered organ germ using organ-inductive potential embryo-derived epithelial and mesenchymal cells. These bioengineering technologies have the potential for realization of future organ replacement therapy.
Journal Title
Current Opinion in Cell Biology
ISSN
09550674
NCID
AA10753496
AA11524927
Publisher
Elsevier
Volume
49
Start Page
84
End Page
90
Published Date
2017-12-28
Rights
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences