ID | 118316 |
Title Alternative | 液性因子および細胞性因子が成長期におけるリン誘導性の血管石灰化を抑制する
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Author |
Okumura, Yosuke
Tokushima University
Adachi, Yuichiro
Tokushima University
Mori, Yuki
Tokushima University
Sakai, Maiko
Tokushima University
Ohnishi, Kohta
Tokushima University
Masuda, Masashi
Tokushima University
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Yamanaka-Okumura, Hisami
Tokushima University|Doshisha Women’s College of Liberal Arts
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Keywords | chronic kidney disease
hyperphosphatemia
fetuin-A
pyrophosphate
alkaline phosphatase
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Content Type |
Thesis or Dissertation
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Description | Hyperphosphatemia is an independent and non-classical risk factor of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). Increased levels of extracellular inorganic phosphate (Pi) are known to directly induce vascular calcification, but the detailed underlying mechanism has not been clarified. Although serum Pi levels during the growth period are as high as those observed in hyperphosphatemia in adult CKD, vascular calcification does not usually occur during growth. Here, we have examined whether the defence system against Pi-induced vascular calcification can exist during the growth period using mice model. We found that calcification propensity of young serum (aged 3 weeks) was significantly lower than that of adult serum (10 months), possibly due to high fetuin-A levels. In addition, when the aorta was cultured in high Pi medium in vitro, obvious calcification was observed in the adult aorta but not in the young aorta. Furthermore, culture in high Pi medium increased the mRNA level of tissue-nonspecific alkaline phosphatase (TNAP), which degrades pyrophosphate, only in the adult aorta. Collectively, our findings indicate that the aorta in growing mouse may be resistant to Pi-induced vascular calcification via a mechanism in which high serum fetuin-A levels and suppressed TNAP expression.
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Journal Title |
Journal of Clinical Biochemistry and Nutrition
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ISSN | 18805086
09120009
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NCID | AA10710201
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Publisher | Society for Free Radical Research Japan
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Volume | 73
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Issue | 3
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Start Page | 198
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End Page | 204
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Published Date | 2023-11-01
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuki Kameiの学位論文として提出され,学位審査・授与の対象となっている。 |
Rights | This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3735号
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Diploma Number | 甲栄第300号
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Granted Date | 2023-03-24
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Degree Name |
Doctor of Nutritional Science
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Grantor |
Tokushima University
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departments |
Medical Sciences
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