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ID 118316
Title Alternative
液性因子および細胞性因子が成長期におけるリン誘導性の血管石灰化を抑制する
Author
Okumura, Yosuke Tokushima University
Adachi, Yuichiro Tokushima University
Mori, Yuki Tokushima University
Sakai, Maiko Tokushima University
Ohnishi, Kohta Tokushima University
Yamanaka-Okumura, Hisami Tokushima University|Doshisha Women’s College of Liberal Arts KAKEN Search Researchers
Keywords
chronic kidney disease
hyperphosphatemia
fetuin-A
pyrophosphate
alkaline phosphatase
Content Type
Thesis or Dissertation
Description
Hyperphosphatemia is an independent and non-classical risk factor of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). Increased levels of extracellular inorganic phosphate (Pi) are known to directly induce vascular calcification, but the detailed underlying mechanism has not been clarified. Although serum Pi levels during the growth period are as high as those observed in hyperphosphatemia in adult CKD, vascular calcification does not usually occur during growth. Here, we have examined whether the defence system against Pi-induced vascular calcification can exist during the growth period using mice model. We found that calcification propensity of young serum (aged 3 weeks) was significantly lower than that of ‍adult serum (10 months), possibly due to high fetuin-A levels. In addition, when the aorta was cultured in high Pi medium in ‍vitro, obvious calcification was observed in the adult aorta but ‍not in the young aorta. Furthermore, culture in high Pi medium increased the mRNA level of tissue-nonspecific alkaline phosphatase (TNAP), which degrades pyrophosphate, only in the adult aorta. Collectively, our findings indicate that the aorta in growing mouse may be resistant to Pi-induced vascular calcification via a mechanism in which high serum fetuin-A levels and suppressed TNAP expression.
Journal Title
Journal of Clinical Biochemistry and Nutrition
ISSN
18805086
09120009
NCID
AA10710201
Publisher
Society for Free Radical Research Japan
Volume
73
Issue
3
Start Page
198
End Page
204
Published Date
2023-11-01
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuki Kameiの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3735号
Diploma Number
甲栄第300号
Granted Date
2023-03-24
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences