Kataoka, Keiko Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nemoto, Hideyuki Tokushima University|Koken Co., Ltd.
Sakurai, Akiko Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yasutomo, Koji Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Shikanai, Masataka Genmai Koso
Fermented brown rice
Type 1 diabetes
Consumption of brown rice and rice bran fermented with Aspergillus oryzae (FBRA) suppresses spontaneously occurring diabetes in female NOD mouse. While control diet-fed mice showed glucosuria and hyperglycemia at around 20 week of age and the ratio reached to 57% at 30 weeks of age, the ratio did not increase in the 0.5% FBRA-containing diet-fed group. The FBRA-fed group at 30 weeks of age kept higher ratio of intact islets and showed significantly lower insulitis score compared to the control diet group, with dose-dependency from 0.25% to 0.5% dietary concentration of FBRA. The percentage of diabetic mice was significantly lower at 24 weeks of age as compared to the control group (p = 0.01, log rank test). These results indicate that the suppressive effects of dietary administration of 0.5% FBRA in delaying the spontaneous onset of diabetes in NOD mice is probably achieved by maintaining the number of intact islets.
Journal of Functional Foods
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
|DOI (Published Version)|
|URL ( Publisher's Version )|
jff_78_104356.pdf 3.01 MB