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ID 116549
著者
Nemoto, Hideyuki Tokushima University|Koken Co., Ltd.
Shikanai, Masataka Genmai Koso
キーワード
Fermented brown rice
Insulitis
NOD mouse
Pdx1
Type 1 diabetes
資料タイプ
学術雑誌論文
抄録
Consumption of brown rice and rice bran fermented with Aspergillus oryzae (FBRA) suppresses spontaneously occurring diabetes in female NOD mouse. While control diet-fed mice showed glucosuria and hyperglycemia at around 20 week of age and the ratio reached to 57% at 30 weeks of age, the ratio did not increase in the 0.5% FBRA-containing diet-fed group. The FBRA-fed group at 30 weeks of age kept higher ratio of intact islets and showed significantly lower insulitis score compared to the control diet group, with dose-dependency from 0.25% to 0.5% dietary concentration of FBRA. The percentage of diabetic mice was significantly lower at 24 weeks of age as compared to the control group (p = 0.01, log rank test). These results indicate that the suppressive effects of dietary administration of 0.5% FBRA in delaying the spontaneous onset of diabetes in NOD mice is probably achieved by maintaining the number of intact islets.
掲載誌名
Journal of Functional Foods
ISSN
17564646
出版者
Elsevier
78
開始ページ
104356
発行日
2021-01-16
権利情報
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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フルテキストファイル
言語
eng
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出版社版
部局
医学系